MAHAKALYANAKAM GHRUTHAM – Benefits, Ingredients, Indications, Dosage, Usage, Preparation, Side effects, Equivalent Medicines, Research Papers

Mahakalyanakam ghrutham is described by Acharya Vagbhata in Ashtanga Hridaya Uttarasthana, Unmada Pratisheda (treatment of insanity). This is given usually in psychological complaints.

INDICATIONS of Mahakalyanaka, Ghrutham

  • Dyspepsia
  • Anaemia
  • Cough
  • Weak intelligence
  • Memory loss
  • Epilepsy
  • Exogenous psychosis
  • Specific disorders of children
  • Poisoning
  • Infertility
  • Diseases of female genital tract
  • Itching and oedema
  • Diabetes, fever
  • Fatigue


Sl. No.English nameSanskrit nameLatin NameProportion
1Indian sarasapillaSaribhaHemidesmus indicus                                          In equal quantity for preparation of decoction
2Black variety of Indian sarasapillaKrishna saribhaIchnocarpous frutescens
3TurmericHaridraCurcuma longa
4Indian beriberiDaruharidraBerberis aristata
5Sal leaved desmodiumSalaparniPseudarthria viscida
6Indian urariaPrisniparniDesmodium gangeticum
7BeautyberryPhaliniCallicarpa macrophylla
8Indian ValerianNataValeriana jatamansi
9Indian night shadeBrihatiSolanum anguivi
10Indian Costus rootKushtaSaussurea costus
11Indian MadderManjishtaRubia cordifolia
12Cobra,s saffronNagakesaraMesua ferrea
13PomegranateDadimaPunica granatum
14Embelia or false black pepperVellaEmbelia ribes
15Himalayan Silver firTalisapatraAbies spectabilis
16CardamomElaElettaria cardamomum
17Spanish jasmineMalathimukulaJasminum grandiflorum
18White water lilyUtpalaKaempferia rotunda
19Wild castor, red physic nutDantiBaliospermum montanum
20Bird cherryPadmakaPrunus cerasoides
21Sandal woodHimaSantalum album
22Ivy gourdViraCoccinia grandis        For kalka
23Black musaliRiddhiCurculigo orchioides
24AsparagusMeda (not available instead using Asparagus)Asparagus racemosus
25Winter cherryKakoli (not available instead using Aswagandha)Withania somnifera
26Monkey tamarindKapikachuMucuna prupriens
27GymnemaVishaniGymnema sylvestre
28Horse vineMashaprniTeramnus labialis
29Wild beanSupyaparniPhaseolus trilous
30Cow’s gheeGhrutham  
31MilkKsheeram 4 times of ghee


Preparation of decoction

The drugs for decoction are taken in equal quantity and cooked in sixteen times water and reduced to 1/4th. The obtained decoction should be four times that of ghee.

Preparation of ghee

The ghee is taken to which decoction and fine paste of drugs are added and cooked in mild fire till the kalka get separated from the ghee. Then taken quantity of milk is added and continued cooking till the paste of drugs attains a stage when it can be rolled into a wick shape. The ghee is then filtered and collected.


Sl. No.Sanskrit nameProperties
1SaribhaIt alleviates vitiated tridoshas, and has anti allergic, anti-toxic and blood purifying action. It is having kushtagna (antileprotic ), jwaragna (febrifuge), balya (nourishing) actions.
2Krishna saribha 
3HaridraAlleviates Kapha pitta doshas, it is having anti allergic, antioxidant, and antimicrobial properties. It is having kandughna (cures itching), kushtanghna (anti-leprotic action), vishaghna (antitoxic effect) properties.
4DaruharidraIt possesses a peculiar antioxidant activity and balances Kapha pitta dosha. It has similar benefits like turmeric and is useful in treating wounds, diabetes, skin diseases, inflammation, poisoning. It relives spasmodic abdominal pain and leucorrhoea and menorrhagia. 
5SalaparniAlleviate vata pitta is having antioxidant, anti-inflammatory, digestive, febrifuge and anticatarrhal actions. It is used in the treatment of oedema, cough, asthma, vomiting, fever, diarrhoea, worm infection and haemorrhoids.
6PrisniparniIt cures vitiation of tridoshas. It is having antimicrobial, antiviral, anti-inflammatory, diuretic, antiemetic, and aphrodisiac and wound healing properties.
7PhaliniIt balances all the vitiated doshas. It has the effect of curing bad odour, excess sweating and dryness. It cures burning sensation, fever, excessive thirst, poisoning, delusion, vomiting and dizziness.
8NataIt balances all vitiated doshas especially kapha vata samana (alleviates kapha and vata). It is useful psychiatric disorders, intoxication, epilepsy, poisoning and headache. It cures blood impurities, skin deses and diseases of eyes.
9BrihatiAlleviate vata kapha dosha. It has properties like carminative, aphrodisiac, cardiac tonic, analgesic, antipyretic and expectorant actions.
10KushtaIt balances kapha due to its bitter taste and vata due to its hot potency. It is used for external application for headache, toothache, gouty arthritis and rheumatic arthritis. It increases sperm count, cures cough, skin diseases, fever, and epilepsy.
11ManjishtaIt alleviates vitiated pitta kapha dosha, astringent and bitter taste, purifies blood, imparts colour to the body, cures ulcer, diabetes, and skin diseases. it is proved to have anthelminthic, and anti-diabetic action.
12NagakesaraNagakesara balances deranged kapha pitta dosha. It is especially useful in treating diseases of urinary tract, poisoning, swelling or oedema, fever and thirst. It is having anti-pruritic, and digestive actions. It is used in treating male infertility.
13DadimaThis is a fruit with innumerable properties. It alleviates all the vitiated doshas. It is advised during fever, thirst and burning sensation. It increases sperm count and a natural aphrodisiac.
14VellaThis is the best drug in treating worm infestation. Useful in treating skin diseases, diabetes, skin diseases, colic pain, bloating, abdominal distension. It helps in expulsion of doshas (vitiated humours) from the head.
15TalisapatraThis drug is famous in treatment of cough, cold and respiratory diseases. It improves digestion and acts as cardio tonic. It cures diseases of mouth, anorexia, bloating, indigestion and vomiting.  
16ElaThis is used as spice. It is having excellent antioxidant property. Alleviates vitiated vata kapha dosha. It relieves dysuria and urinary retention. Cures cough, respiratory diseases, anorexia, neuralgia, burning sensation. Used to cure vomiting, IBS, bloating, etc.
17MalathimukulaAlleviates Tridosha, it is having hot potency, bitter and astringent tastes. It is good for eyes, has anti-toxic effect, and cures ulcers. It is proved to have antiseptic and anthelminthic properties.
18UtpalaBalances pitta kapha dosha. This is efficient in curing diarrhoea, colitis, IBS. Useful in bleeding disorders, burning sensation of eyes, neuropathy, fatigue, etc.
19DantiThe drug spreads very easily throughout body and has a quick action. It is used in the treatment of wounds, skin diseases, cough, asthma, neuralgia, ascitis, oedema, haemorrhoids, etc.
20PadmakaIt is used to treat skin diseases, burning sensation, herpes, excessive thirst, fever, vomiting, bleeding disorders, vomiting, and dizziness. It has action in insanity, and acts to protect pregnancy.
21HimaIt is famous for fragrance property and so relieves bad odour. Cures gastritis and burning sensation in hands and feet. It balances kapha and pitta dosha. Relieves tiredness, fatigue, and psychiatric disorders like Mania, Schizophrenia, etc.
22ViraIt balances kapha pitta dosha. It cures respiratory diseases, cough, anaemia, bleeding diseases, and excess dose induces vomiting.
23RiddhiIt is aphrodisiac, anti-ageing, nourishing, and cures burning sensation, gastritis, hyper acidity
24MedaIt acts as cardio tonic, improves intelligence, strength, immunity and is aphrodisiac.
25KakoliIt is aphrodisiac, and improves strength, immunity. This nourishing and acts as rejuvenating.
26KapikachuIt is aphrodisiac and used in various neurological conditions. It is used in parkinsonism management. It is nourishing, anti-ageing, and improves intelligence.
27VishaniIt improves digestive strength and acts as mild laxative, cardio tonic. It is indicated in skin diseases, diabetes, worm infestations.
28MashaprniIt is highly nutritious, and used for treating fatigue, muscle wasting, bleeding disorders, etc
29SupyaparniIt is aphrodisiac and used in treating oligospermia, gout, neuropathy, worm infections. It is nourishing and improves body weight.

The drugs have properties of vrishya (aphrodisiac) and action in reducing vata, pitta dosha. It has specific action in nervous system. It can control vata dosha.



5 to 10 g of ghee is taken with hot water or milk as adjuvent. The adjuvent can be chosen according to the disease. For oleation therapy the dose is decided considering the digestive capacity of the individual.


The yoga, meditation and pranayama can be done which is conducive to the disease in which Kalyanaka ghrutham is given. Usually the practice of yoga and meditation can maintain a healthy mental status. The desirable postures are,

  • Sooryanamaskara
  • Gomukhasana
  • Ardhamatsyendrasana
  • Padmasana
  • Vajrasana
  • Setubandhasana
  • Halasana
  • Anuloma viloma Pranayam


No specific congenial food or regimens are specified in the formulation. But according to the disease in which the ghee is given the dietary advice can be given. It is desirable to eat light easy to digest and hot food.

Patients having dyslipidaemia and other cardiac disease it is better to take doctor’s advice before intake of ghee.


It is desirable to avoid smoking, alcohol, junk foods, fried, dry foods, night awakening, day sleep, etc.


No side effects are noticed



Ashtanga Hridaya Uttarasthana unmada pratisheda 


  • Vaidyaratnam oushadasaala
  • Aryavaidyasala Kottakkal
  • SNA oushadhasala
  • Kerala Ayurveda Pharmacy-
  • AVN
  • AVP
  • Sitaram
  • Nagarjuna


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